Carlos Tirado, Ph.D., F.A.C.M.G.

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Assistant Professor, Pathology & Laboratory Medicine at UCLA

 

 

Bio


Dr. Tirado is a Clinical Cytogeneticist with interests in hematological malignancies as well as solid tumors. Dr. Tirado has been doing research in pancreatic cancer, prostate cancer and leukemias. Dr. Tirado has completed his Fellowship in Clinical Cytogenetics at Duke University Medical Center in 2004. He joined Quest Diagnostics Nichols Institute in Chantilly. He then became an Assistant Professor at University of South Carolina School of Medicine. In 2008 he became an Associate Director of Cytogenetics at UTSouthwestern Medical Center where he also was running the ABMG Fellowship in Clinical Cytogenetics. On September 1st, 2011 he came on board at UCLA as an Associate Director. Dr Tirado is also an Adjunct Professor at MD Anderson Health Sciences and UT San Antonio. Dr. Tirado’s research interests is cancer cytogenetics specifically solid tumors and hematological malignancies. 


Publications

 

Amarillo I, Bui PH, Kantarci S, Rao PN, Shackley BS, Garcia R, Tirado CA. 2013. Atypical rearrangement involving 3’-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression. Molecular Cytogenetics 6(1):5. 

Boles JW, DeNicola M, Collins R, Garcia R, Patel S, Satayasoontorn K, Tirado CA. 2013. A CML case with a cryptic insertion of the ABL1 gene of chromosome 9 into 22 resulting in a fusion signal on the derivative 22: 46,XY.ish ins(22;9)(q11.2;q34q34)(BCR+,ABL1+). The Journal of the Association of Genetic Technologists 2013; 39(1): 21-22. 

Boles JW, Tirado CA. 2013. Epigenetic events in acute myeloid leukemia: an update. The Journal of the Association of Genetic Technologists 39(2):61-65. 

Tirado CA, Shabsovich DS, Ji J, Dawson D. Pancreatic tumors: An Overview. Atlas Genet Cytogenet Oncol Haematol. August 2013. URL: http://AtlasGeneticsOncology.org/Tumors/PancreaTumOverviewID5054.html 

James AW, Tirado CA, Levine B, Dry S. 2013. Abnormal Karyotypes in Osteochondroma: Case Reports and Literature Review. Manuscript submitted and accepted in the Journal Bone Joint Surgery. 

Tirado CA, Shabsovich, D, DeNicola M, Rao D, Delgado P., Jarrin A, Yang L and Rao, N. A case of pediatric acute lymphoblastic leukemia with a (9;12) translocation involving JAK2 and rearrangement of MLL at 11q23 with an apparent insertion at 6q27. Biomarker Research 2013, 1:31. 

DeNicola M, Pullarkat S, Yea S, Delgado P., Yang L, Rao N and Tirado CA. 2013. A case of hyperdiploidy in CLL/SLL: A Rare Cytogenetic Event Associated with Poor Prognosis. Paper accepted at the Journal of American Genetic Technologists. 

Tirado CA, Chen W, Garcia R, Rao PN. 2012. Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature. Journal of Hematology & Oncology 5:54. 

Delgado P, Starshak P, Rao PN, Tirado CA. 2012. T-cell prolymphocytic leukemia (PLL), a heterogeneous disease: a comprehensive molecular and cytogenetic update. The Journal of the Association of Genetic Technologists 38(4):193-198. 

Wakim J, Tirado CA, Dowel J, Chen W. 2012. Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia: A report of the first case and review of the literature. Cancer Genetics 205:124-127. 

Tirado CA, Starshak P, Delgado P, Rao PN. 2012. T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach. Experimental Hematology & Oncology Journal 1:21. 

Wakim J, Tirado CA. 2012. Acute promyelocytic leukemia lacking the classic translocation t(15;17), myeloid leukemia - clinical diagnosis and treatment. Steffen Koschmieder and Utz Krug (Ed.), ISBN: 978-953-307-886-1, InTech, Available from: http://www.intechopen.com/articles/show/title/acute-promyelocytic-leukemia-lacking-the-classic-translocation-t-15-17- 

Wakim J (First Author), Tirado CA (First Author), Chen W, Collins R. 2011. t(8;22)/BCR-FGFR1 myeloproliferative disorder presenting as B-acute lymphoblastic leukemia: report of a case treated with sorafenib and review of the literature. Leukemia Research 35:e151-e153. 

Hiemenz M, Chen W (Co-author), Winick N, Tirado CA. 2011. Coexistence of t(12;21)(p13;q22)/ETV6-RUNX1 and 11q23/MLL rearrangements in B lymphoblastic leukemia: a third reported case and review of the literature. The Journal of the Association of Genetic Technologists 37(4):213-216. 

Tirado CA, Gotway G, Torgbe E, Valdez F, Suterwala M, Iyer S, Garcia R, Shah N, Dallaire S, Appleberry T, Pichurin P, Koduru P. 2011. Recombinant chromosome 7 in a mosaic triple x/turner patient. American Journal of Medical Genetics Part A 158A:206-214. 

Tirado CA, Chen W, Huang LJ, Laborde C, Hiemenz M, Lou Z, Valdez F, Winick N, Ho K, Koduru P. 2010. Novel JAK2 rearrangement resulting from a t(9;22)(p24;p11.2) in B lymphoblastic leukemia. Leukemia Research 34: 1674-1676. 

Jose S, Gotway G, Garcia R, Vaziri A, Tirado CA. 2010. 8p11-12 FGFR1 rearrangements in hematological malignancies: review of the literature. The Journal of the Association of Genetic Technologists 36(4):203-208. 

Ho K, Valdez F, Garcia R, Tirado CA. 2010. Jak2 translocations in hematological malignancies: review of the literature. The Journal of the Association of Genetic Technologists 36(3):107-109. 

Wang HY and Tirado CA. 2010. Precursor B-cell acute lymphoblastic leukemia with t(8;21) translocation involving AML and ETO. Human Pathology 41(2):286-292. 

Tirado CA, Valdez F, Arbini A, Klesse L, Karandikar N, Fustino N, Uddin N, Collins R, Patel S, Smart RL, Garcia R, Doolittle J, Chen W. 2010. Acute myeloid leukemia with inv(16), 3’CBFB deletion, variant t(9;22) & del(7)(q) in a pediatric patient, a case report and review of the literature. Cancer Genetics and Cytogenetics 200:54-59. 

Lou Z, Zhang J, Tirado CA, Slone T, Zaremba CM, Oliver D, Chen W. 2010. Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23); MLL-MLLT10. Leukemia Research 34:1107-1109. 

Tirado CA, Chen W, Valdez F, Karandikar N, Arbini A, Acevedo I, Garcia R, Davila O, Smart RL, Matthews E, Kirk A, Collins RH. 2010. Unusual presentation of myeloid sarcoma with a cryptic PML-RAR? rearrangement involving the atrium. Cancer Genetics and Cytogenetics 200:47-53. 

Tirado CA, Henderson S, Uddin N, Stewart E, Iyer S, Ratner IM, Matthews E, Doolittle J, Garcia R, Valdez F, Dallaire S, Payne D, Collins R. 2009. Cytogenetic and molecular characterization of a partial trisomy 2p arising from inverted duplication of 2p with terminal deletion of 2pter. Am J Med Genet Part A 149A(11):2507-2512. 

Tirado CA, Chen W, Valdez FJ, Henderson S, Horna P, Doolittle J, Garcia R, Auchus M, Collins RH. 2009. Acute myeloid leukemia (M2) with a cryptic RUNX1/RUNX1T1 t(1;21;8)(p36.1;q22;q22) variant. Cancer Genetics and Cytogenetics 193(1):67-69. 

Souza LD, Tirado CA, Brooks KA, Corning K, Clarkson K, Gregg AR, Best RG. 2008. A case of a 69,XXY infant with a survival to age 40 months. “Humen” Año 4, Número (Revista de Investigacion de la Universidad Catolica Santo Toribio de Mogrovejo, Chiclayo, Peru). 

Tirado CA, Meloni-Ehrig AM, Edwards T, Scheerle J, Burks K, Repetti C, Christacos NC, Kelly JC, Greenberg J, Murphy C, Croft CD, Heritage D, Mowrey PN. 2007. Cryptic ins(4;11)(q21;q23q23) detected by fluorescence in situ hybridization: a variant of t(4;11)(q21;q23) in an infant with a precursor B-cell acute lymphoblastic leukemia report of a second case. Cancer Genet Cytogenet 174(2):166-9. 

Tirado CA, Meloni-Ehrig AM, Wallenhorst E, Burks K, Scheerle J, Morillon M, Kelly JC, Heritage D, Spira A, Croft CD, Glasser L, Butera JN, Mowrey P. 2006. Dicentric (17;20)(p11.2;q11.2): an uncommon cytogenetic abnormality in myeloid malignancies. Cancer Genet Cytogenet 170(1):61-4. 

Franco LM, Goldstein J, Prose NS, Selim MA, Tirado CA, Coale MM, McDonald MT. 2006. Incontinentia pigmenti in a boy with XXY mosaicism detected by fluorescence in situ hybridization. J Am Acad Dermatol 55(1):136-8. 

Tirado CA, Sebastian S, Moore JO, Gong JZ, Goodman BK. 2005. Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12 and 17 resulting in ETV6(TEL) and ABL fusion. Cancer Genet Cytogenet 157(1):74-7. 

Meloni-Ehrig AM, Tirado CA, Chen K, Jahn J, Suchan S, Scheerle J, Crosby MG, Meany H, Seibel N, Leitenberg D, Heritage DW, Mowrey PN. 2005. Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 161(1):82-5. 

Tirado CA, Jahn JA, Scheerle J, Eid M, Meister RJ, Christie RJ, Croft CD, Wallingford S, Heritage DW, Mowrey PN, Meloni-Ehrig AM. 2005. Variant acute promyelocytic leukemia translocation (15;17) originating from two subsequent balanced translocations involving the same chromosomes 15 and 17 while preserving the PML/RARA fusion. Cancer Genet Cytogenet 161(1):70-3. 

Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF. 2004. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J 23(15):3164-74. 

Safley AM, Sebastian S, Collins TS, Tirado CA, Stenzel TT, Gong JZ, Goodman BK. 2004. Molecular and cytogenetic characterization of a novel translocation (4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. Genes Chromosomes Cancer 40(1):44-50. 

Tirado CA, Lager J, Rosoff PM, Golembiski-Ruiz V, Gong JZ, Goodman BK. 2004. A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. Cancer Genet Cytogenet 154(1):57-9. 

Tirado CA, Golembiewski-Ruiz V, Horvatinovich J, Moore JO, Buckley PJ, Stenzel TT, Goodman BK. 2003. Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). Cancer Genet Cytogenet 145(1):31-7. 

Banik SS, Guo C, Smith AC, Margolis SS, Richardson DA, Tirado CA, Counter CM. 2002. C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. Mol Cell Biol 22(17):6234-46. 

Tirado CA, Sandberg AA, Stone JF. 1999. Identification of a novel amplicon at 1q31 in pancreatic cancer cell lines. Cancer Genet Cytogenet 113(2):110-114.