The first case of Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia

Abstract

In chronic myelogenous leukemia, chromosomal abnormalities in Philadelphia-negative cells are rare and usually transient, but can infrequently lead to myelodysplastic syndrome and/or acute myeloid leukemia. We report an 82-ear-old patient with an 11-year history of chronic myelogenous leukemia, in complete cytogenetic response, who developed Philadelphia-negative t(15;17)/PMLRARA acute promyelocytic leukemia. This isolated case reaffirms several important clinicopathologic and biologic aspects of chronic myelogenous leukemia, and sheds a unique light on its Philadelphia-negative hematopoiesis. It also underlines the importance of continued cytogenetic monitoring of patients in complete cytogenetic response for the emergence of new chromosomal abnormalities.
Keywords: Chronic myeloid leukemia, chromosomal abnormalities, Philadelphia chromosomenegative, acute promyelocytic leukemia, imatinib
 
Download the full paper HERE.

1 comment

  • RafaelVal
    RafaelVal 21 Jun 2017

    generic cialis without rx
    Levitra
    where can i get viagra pills
    http://levitraclr.com/ - Levitra Cost
    cheap viagra tablets sale

    reply