Variant acute promyelocytic leukemia translocation (15;17) originating from two subsequent balanced translocations involving the same chromosomes 15 and 17 while preserving the PML/RARA fusion


Fluorescence in situ hybridization (FISH) analysis of the bone marrow of a 24-year-old man diagnosed with acute promyelocytic leukemia (APL) revealed a variant pattern with one fusion signal instead of the typical two fusions expected with the probe set used. The combined FISH and conventional chromosome analyses suggested that two subsequent translocations had occurred in this patient involving the same chromosomes 15 and 17. As the prognostic outcome in APL is strictly associated with the presence of a PML/RARA fusion, it is useful and necessary to perform both cytogenetic and FISH analyses of a variant t(15;17) to determine the status of the PML/RARA fusion.  2005 Elsevier Inc. All rights reserved.
Download the full paper HERE.


  • LarryNep
    LarryNep 30 May 2017

    hay cialis generico en mexico - Buy Viagra Online

    Buy Viagra
    buy levitra with no prescription

  • Dora
    Dora 26 May 2017

    Exceptional post however , I was wondering if you could
    write a litte more on this topic? I'd be very grateful if you could elaborate a little bit more.

  • Yanira
    Yanira 27 Nov 2015

    What's up it's me, I am also visiting this website on a regular basis,
    this website is genuinely nice and the viewers are really sharing
    pleasant thoughts.

  • help me get more followers on instagram
    help me get more followers on instagram 15 Sep 2015

    Heya i'm for the first time here. I came across this board
    and I find It really useful & it helped me out a lot.
    I hope to give something back and help others
    like you aided me.

  • best dvd ripper review
    best dvd ripper review 11 Sep 2015

    These are really enormous ideas in on the topic of blogging.
    You have touched some nice points here. Any way keep up

  • zune downloads
    zune downloads 07 Sep 2015

    I love it when folks get together and share views.
    Great website, continue the good work!

  • login login 24 Aug 2015

    Adding a calendar to your web page has never been easier.
    Google started as being a search engine and also, since has added many applications.