A Cryptic t(11;14) Translocation in Mantle Cell Lymphoma Highlights the Importance of FISH

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm composed of monomorphic small to medium-sized atypical lymphocytes arising from naïve mantle zone B-cells, with a generally aggressive and incurable clinical course. The t(11;14)(q13;q32) between IGH@ and CCND1 is present in almost all cases of MCL. Secondary cytogenetic abnormalities are common, and have been associated in some cases with clinical progression. Variant and cryptic t(11;14) translocations have been reported as well. Herein, we present the case of an 80-year old woman with classical MCL, and a cryptic t(11;14) translocation detected by fluorescence in situ hybridization (FISH), and not by conventional cytogenetics. FISH on previously G-banded metaphases showed a cryptic CCND1-IGH@ fusion signal on a derivative chromosome 10, and another fusion signal on one of the abnormal copies of chromosome 11. Cases such as this highlight the importance of FISH studies as part of an algorithmic and multidisciplinary approach to diagnosis.
Key Words: Mantle Cell Lymphoma, cryptic t(11;14), FISH on previously G-banded metaphases
Download the full paper HERE.

226 comments

  • JohnnyDup
    JohnnyDup 23 Aug 2017

    how to buy levitra
    buy levitra
    buying levitra online safe
    buy levitra
    buy generic levitra canada

    reply
  • ToshkaWah
    ToshkaWah 23 Aug 2017

    cialis envoi rapide

    http://cialisonlineger.com/ - buy cialis online

    cialis

    cialis vs questions levitra vs

    reply
  • ToshkaWah
    ToshkaWah 23 Aug 2017

    buy cialis doctor online

    http://cialisonlineger.com/ - cialis

    cialis online

    buy cialis doctor online

    reply
  • CharlesHenue
    CharlesHenue 22 Aug 2017

    viagra 100mg pfizer rezeptfrei
    Generic Viagra Online
    where buy viagra in uk
    Buy Viagra Online
    safest way to buy viagra online

    reply
  • CharlesHenue
    CharlesHenue 22 Aug 2017

    where to buy generic viagra in uk
    Viagra Generic
    what will 50mg of viagra do
    Generic Viagra Online
    viagra sale cheap uk

    reply
  • NoilWah
    NoilWah 22 Aug 2017

    cialis en gel

    discount cialis

    cialis

    cialis drug impotence

    reply
  • NoilWah
    NoilWah 21 Aug 2017

    cialis online softtabs

    buy generic cialis

    cialis

    cialis drug impotence

    reply
  • levitra price
    levitra price 21 Aug 2017

    levitra buy canada
    levitra
    best place buy levitra
    levitra price
    where to buy levitra

    reply
  • GeorgePoela
    GeorgePoela 19 Aug 2017

    cheapest levitra
    levitra cost
    generic levitra sale
    buy levitra
    levitra super active cheap us

    reply
  • RobertAlect
    RobertAlect 18 Aug 2017

    cheapest viagra cialis levitra
    buy levitra
    levitra buy
    levitra
    buy levitra discount

    reply