A Cryptic t(11;14) Translocation in Mantle Cell Lymphoma Highlights the Importance of FISH

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm composed of monomorphic small to medium-sized atypical lymphocytes arising from naïve mantle zone B-cells, with a generally aggressive and incurable clinical course. The t(11;14)(q13;q32) between IGH@ and CCND1 is present in almost all cases of MCL. Secondary cytogenetic abnormalities are common, and have been associated in some cases with clinical progression. Variant and cryptic t(11;14) translocations have been reported as well. Herein, we present the case of an 80-year old woman with classical MCL, and a cryptic t(11;14) translocation detected by fluorescence in situ hybridization (FISH), and not by conventional cytogenetics. FISH on previously G-banded metaphases showed a cryptic CCND1-IGH@ fusion signal on a derivative chromosome 10, and another fusion signal on one of the abnormal copies of chromosome 11. Cases such as this highlight the importance of FISH studies as part of an algorithmic and multidisciplinary approach to diagnosis.
Key Words: Mantle Cell Lymphoma, cryptic t(11;14), FISH on previously G-banded metaphases
Download the full paper HERE.

312 comments

  • French Homework
    French Homework 21 Oct 2017

    buy essay buy essay college essay writing help buy essays

    reply
  • Payday Express
    Payday Express 19 Oct 2017

    loan 10 top loan companies payday loans for bad credit bad credit payday loans

    reply
  • top 10 mail order pharmacies
    top 10 mail order pharmacies 17 Oct 2017

    http://canadianpharmaciesworld.com/

    reply
  • GilbertBah
    GilbertBah 12 Oct 2017

    viagra 25mg
    viagra on line
    can buy viagra over counter us
    viagra for sale uk only
    100mg 50mg viagra

    reply
  • come_viagra
    come_viagra 03 Oct 2017

    Re: http://canadianviagrats.com/ , 's diminishing effect Sonvolt, you know, it's not been perfect every time for me.

    reply
  • MichaelBen
    MichaelBen 25 Sep 2017

    can you buy viagra at walgreens
    viagra online
    viagra to buy online
    cheap viagra uk next day delivery
    viagra india online purchase

    reply
  • MichaelBen
    MichaelBen 25 Sep 2017

    buy viagra stores uk
    viagra cheap generic
    mezza pillola viagra
    buy viagra at walmart
    viagra for men online

    reply
  • SteveDeems
    SteveDeems 25 Sep 2017

    buy cialis daily dose
    buy cialis online
    cialis professional for sale
    buy cialis
    cialis discount coupon

    reply
  • Nickdew
    Nickdew 25 Sep 2017

    free online porn chat online payday loans for bad credit

    reply
  • Michaelgrede
    Michaelgrede 25 Sep 2017

    cheap cialis online no prescription
    cialis buy
    how to order cialis
    cialis online
    buy cialis hong kong

    reply