Acute Promyelocytic Leukemia Lacking the Classic Translocation t(15;17)

Introduction

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by the reciprocal translocation t(15;17)(q22;q12) resulting in the fusion gene PML-RARA and an oncoprotein that impairs myeloid differentiation (Arber et al., 2008; de The et al., 1990; Rowley et al., 1977). Morphological and clinical characteristics include hypergranular leukemic promyelocytes, Auer rods, and coagulopathy. The use of all-trans retinoic acid (ATRA) has revolutionized the management of this disease that has become the most curable form of AML in adults (Castaigne et al., 1990; Tallman et al., 1997). In relapsed APL, arsenic trioxide can induce complete morphological, cytogenetic and molecular remission (Douer and Tallman, 2005; Soignet et al., 1998).
Cases lacking the classic t(15;17) are divided into two separate groups that behave differently and are now considered different disease entities (Arber et al., 2008). The first group represents cryptic and complex APL where t(15;17) is absent on routine cytogenetic studies but PML-RARA is present on molecular studies (Grimwade et al., 2000). This group shares the same phenotype, prognosis, and sensitivity to ATRA as classic APL, and is thus managed similarly. The second group, “AML with a variant RARA translocation”, is no longer considered part of APL and includes acute myeloid leukemias with translocations involving RARA and a variety of partner genes other than PML (Arber et al., 2008). Compared to classic APL, these leukemias often exhibit significant differences in malignant phenotype and sensitivity to ATRA which will be further explored in this chapter.
Download the full paper HERE.

30 comments

  • SteveDeems
    SteveDeems 25 Sep 2017

    buy cialis uk online
    buy cialis online
    can buy cialis canada
    buy cialis online
    cheap generic cialis uk

    reply
  • RolandFouck
    RolandFouck 23 Sep 2017

    buy cialis new delhi
    online cialis
    buy cialis online discount
    buy cialis online
    cialis pills for cheap

    reply
  • WilliamPiodo
    WilliamPiodo 19 Sep 2017

    canadian online pharmacy
    Canadian Online Pharmacies
    Legitimate Online Pharmacies
    Canadian Drugs
    pharmacy direct

    reply
  • Jasonnelty
    Jasonnelty 10 Sep 2017

    how to recover from heroin addiction
    drug and alcohol rehab
    alcohol rehab treatment
    rehab addict
    drug addiction detox

    reply
  • Ronaldric
    Ronaldric 09 Sep 2017

    symptoms of amphetamine abuse
    alcohol rehab centers
    rehab for weed smokers
    alcohol rehab
    speed addiction treatment

    reply
  • Franksnurl
    Franksnurl 07 Sep 2017

    signs of marijuana addiction in adults
    alcohol rehab houston
    crack addiction help
    alcohol rehab
    long term and short term effects of cocaine

    reply
  • RichardKah
    RichardKah 06 Sep 2017

    easy get prescribed viagra
    viagra without prescription
    cost of viagra per pill walgreens
    viagra without a doctor prescription
    cheap viagra adelaide

    reply
  • AnthonyNok
    AnthonyNok 04 Sep 2017

    how much does a viagra pill cost
    viagra without prescription
    viagra prices 2012
    viagra without prescription
    generic viagra in cvs

    reply
  • EddieOrnam
    EddieOrnam 02 Sep 2017

    qual generico do viagra
    viagra without prescription
    viagra generico italia
    viagra without doctor
    viagra super active cheap

    reply
  • BobbyACUND
    BobbyACUND 01 Sep 2017

    order cialis daily use
    cialis professional online
    genuine cialis sale
    buy cialis professional online
    cialis uk buy

    reply