C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity

Abstract Most human cancer cells are thought to acquire the ability to divide beyond the capacity of normal somatic cells…

Rate this item
(2 votes)
Rate this item
(2 votes)

A Chronic Myelogenous Leukemia (CML) Case with a Cryptic Insertion of the ABL1 Gene of Chromosome 9 into 22 Resulting in a Fusion Signal on the Derivative 22: 46,XY.ish ins(22;9)(q11.2;q34q34)BCR+,ABL1+

Abstract Chronic myelogenous leukemia (CML) is characterized by the specific cytogenetic translocation t(9;22)(q34;q11.2), also called the Philadelphia (Ph) chromosome. We…

Rate this item
(2 votes)

Genes, Chromosomes, and Disorders of Sex Development: An Update

Abstract Disorders of sex development (DSD) comprise a group of conditions in which genotypes do not correlate with the typical…

Rate this item
(2 votes)

A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27

Abstract Background: B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in pediatric patients and the leading cause of…

Rate this item
(2 votes)

The first case of Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia

Abstract In chronic myelogenous leukemia, chromosomal abnormalities in Philadelphia-negative cells are rare and usually transient, but can infrequently lead to…

Rate this item
(2 votes)

Incontinentia pigmenti in a boy with XXY mosaicism detected by fluorescence in situ hybridization

Introduction We report the case of a male infant with incontinentia pigmenti (MIM 308310) and low-grade XXY mosaicism. Fluorescence in…

Rate this item
(1 Vote)

Acute myeloid leukemia (M2) with a cryptic RUNX1/RUNX1T1 t(1;21;8)(p36;q22;q22) variant

Introduction The t(8;21) translocation occurs in 5e12% of acute myeloid leukemia (AML) cases, often occurring in the younger population. This…

Rate this item
(1 Vote)

Dicentric (17;20)(p11.2;q11.2): an uncommon cytogenetic abnormality in myeloid malignancies

Abstract We report on two patients with myeloid disorders and complex karyotypes including a dicentric chromosome, dic(17;20)(p11.2;q11.2), resulting in the…

Rate this item
(1 Vote)
Page 2 of 3